Endocrine Abstracts

Background and aim: The clinical significance of papillary thyroid microcarcinoma (PTMC) is debatable. The purpose of this study is to analyse the clinicopathological characteristics of patients with PTMC and document the risk factors for poor prognosis.Materials and methods: Eighty-eight patients (18 males, 70 females) were included in the study. Clinical and laboratory parameters were recorded.Results: The mean age of the patient...

Introduction: A pituitary adenoma is directly assumed to originate from anterior pituitary. It is expected that pathologies of posterior hypophysis cause diabates insipitus (DI). However recently posterior pituitary tumors (PPTs) are also declared which are not associated with DI in contrast to what is expected. Rather they have a clinical and radiologic presentation akin to anterior pituitary adenomas. Differentiation of two conditions is mainly based on pathologic immunohyst...

Objective: Euthyroid patients undergoing thyroidectomy were reported to gain weight than their matched counterparts. The etiology is still unknown. Serum adiponectin and leptin levels are related to fat mass and thyroid hormones. We aimed to evaluate the influence of thyroidectomy on body composition, serum adiponectin, leptin levels in euthyroid obese and non-obese patients who underwent total thyroidectomy for goiter.Methods: We conducted a prospective...

Objective: Rosacea is an inflammatory dermatosis. Telangiectasias, edema, erythema, and acneiform eruptions are the main symptoms. Several genetic and environmental factors have been linked to rosacea; however, the etiology of the disease is still not known. It is considered a systemic disease rather than a skin disorder. Endocrine-disrupting chemicals are substances people are exposed to through water, food, self-care products, and the environment. They interfere with normal ...

Glycogen storage disease 1A (GSD1A) is an inherited metabolic disorder caused by glucose-6-phosphatase (G6PC) deficiency. Patients with GSD1A present disturbed glucose homeostasis and exhibit glycogen accumulation accompanied by hepatomegaly, hypoglycemia, lactic acidosis and hyperlipidemia. However, there are currently no licensed treatments for GSD1A, and human in vitro systems for disease modelling and drug screening are lacking. We aimed to develop a human hepatoc...

Objective: The aim of this study was to evaluate paraoxonase-1 (PON1) activities and its association with oxidative stress status in autoimmune thyroid disease (AITD).Materials and methods: Patients with 25 Hashimoto thyroiditis (HT) and 25 Graves’ disease (GD) and 27 healthy controls were enrolled in the study. Blood samples were obtained in euthyroid period and 3 months after the initiation of medical treatment. ...

Background: Endocrine-related adverse effects of immune check-point inhibitors (ICIs) have been identified in growing number of cancer patients.Case presentation: A 49-year-old male with laryngeal cancer applied to ouroutpatient clinic with weakness, loss of appetite, weight loss, nausea and vomiting for the last three weeks. He was diagnosed with T3N1M0 laryngeal squamous cell cancer seven months before this admission and was given concurrent cisplatin ...

Introduction: Increased adrenocortical production appears to be associated with acne and hirsutism in PCOS. However, the etiological role of androgens in the pathogenesis of acne per se is far from being clear. In the present study, we aimed to evaluate adrenocortical function in women with post-adolescent severe acne in comparison with patients with PCOS and healthy women.Design: The study included 32 women with post-adolescent severe acne, 32 ...

Background and aim: Serum Cystatin C has been shown to be associated with the progression to prediabetes and type 2 diabetes mellitus. High cystatin levels were also found to be associated with body mass index. The aim of this study was to evaluate cystatin C levels in diabetic and prediabetic patients ant its association with anthropometric measurements and insulin resistance.Methods: Twenty four patients with diabetes, 17 patients with prediabetes and ...

Introduction: Green tea consumption has been reported to be associated with weight loss although the results of the studies are inconclusive and potential underlying mechanism is not yet clear. We aimed to evaluate the effect of green tea extract on weight loss, body composition and resting energy expenditure in obesity.Methods: Twenty-nine obese patients (body mass index (BMI) >30 kg/m2) were included in the study. Weight, BMI, waist circ...